E45 Dermatological Cream Treatment for Dry Skin. Effective and pleasant to use, E45 Cream has been clinically proven to treat and soothe dry, itching, flaking, chapped, rough and calloused skin, sunburn and detergent hands. Its non greasy emollient formulation is quickly absorbed by your skin, leaving it soft, comfortable and relieved. E45 Cream is recommended for more serious dry skin conditions such as eczema, dermatitis, ichthyosis and certain dry cases of psoriasis. E45 Cream can be used everyday by the whole family including babies.